Spotlight on Research – Garcia Lab
The Garcia Lab is focused on the development and application of quantitative mass spectrometry (MS) based proteomics and related computation for understanding dynamic protein and proteome post-translational modifications (PTMs). One particular interest is in investigating epigenetic histone PTMs and their role in regulating gene expression in normal and disease physiology. Our lab utilizes high resolution and high-throughput mass spectrometry and further develops improved sample preparation approaches and advanced instrument methods to sequence intact proteins (Top Down MS) and peptides (Bottom Up MS) with high sensitivity. All of these advances have been employed to study several epigenetic targets involved in processes such as cancer, neurological development, viral infection and cellular reprogramming.