Linda J. Pike, Ph.D.

Alumni Endowed Professor

Biochemistry and Molecular Biophysics

Lab Website
Graduate Programs (DBBS)
Publications (PubMed / NIH)

Office: 206 McDonnell Sciences Building
Phone: 314-362-9502


Mechanism of action of growth factors; polyphosphoinositide metabolism.

Linda Pike's research

Select Publications

Gill K., Macdonald-Obermann J.L., & Pike L.J. (2017). “Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent.” J Biol Chem. 2017 Dec 15;292(50):20744-20755. doi: 10.1074/jbc.M117.802553. Epub 2017 Oct 26. (Abstract)

Needham S.R., Roberts S.K., Arkhipov A., Mysore V.P., Tynan C.J., Zanetti-Domingues L.C., Kim E.T., Losasso V., Korovesis D., Hirsch M., Rolfe D.J., Clarke D.T., Winn M.D., Lajevardipour A., Clayton A.H., Pike L.J., Perani M., Parker P.J., Shan Y., Shaw D.E., and Martin-Fernandez M.L.
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Nat Commun. 7:13307 (2016) (Abstract)

Ronan, T., Macdonald-Obermann, J.L., Huelsmann, L., Bessman, N.J., Naegle, K.M. and Pike, L.J.
Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.
J. Biol Chem 291:5528-5540 (2016). (Abstract)

Macdonald-Obermann, J.L. and Pike, L.J.
Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.
J. Biol Chem 289:26178-26188 (2014). (Abstract)

Macdonald-Obermann, J.L., Adak, S., Landgraf, R., Piwnica-Worms, D. and Pike, L.J.
Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging.
J. Biol Chem 288:30773-30784 (2013). (Abstract)

Li, Y., Macdonald-Obermann, J., Westfall, C., Piwnica-Worms, D. and Pike, L.J.
Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization.
J Biol Chem 287:31116-31125 (2012). (Abstract)

Pike, L.J.
Negative co-operativity in the EGF receptor.
Biochem Soc Trans 40:15-19 (2012). (Abstract)

Macdonald-Obermann, J.L, Piwnica-Worms, D. and Pike, L.J.
Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging.
Proc Natl Acad Sci USA 109:137-42 (2012). (Abstract)

Adak, S., Yang, K.S., Macdonald-Obermann, J. and Pike, L.J.
The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding.
J Biol Chem 286:45146-45155 (2011). (Abstract)

Adak, S., Deandrade, D. and Pike, L.J.
The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction.
J Biol Chem 286:1545-1555 (2012). (Abstract)