Author: Nicholas Caito

Single Molecule Workshop: Structural Dynamics of Biomolecules and 34th Robert E. Olson Lecture

The Single Molecule Workshop will be held at Saint Louis University, in the Education Union Auditorium, on Wednesday, December 6th, 2017.

5th Annual Workshop: Structural Dynamics of Biomolecules
10:00 am – 2:30 pm

Frontiers in Molecular Medicine and 34th Robert E. Olson Lecture
3:00 – 4:00 pm

Speakers include Enrico Di Cera, M.D., Colin Nichols, Ph.D., Frances Yap, Ph.D., Yann Chemla, Ph.D., Kathleen Hall, Ph.D., and Beniamino Barbieri, Ph.D.

More information and registration can be found on HERE (slu.edu).

Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii.

Rutaganira F.U., Barks J., Dhason M.S., Wang Q., Lopez M.S., Long S., Radke J.B., Jones N.G., Maddirala A.R., Janetka J.W., El Bakkouri M., Hui R., Shokat K.M., and Sibley L.D.
Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii.
J Med Chem. doi: 10.1021/acs.jmedchem.7b01192. (2017) (Abstract)

Peptide-Level Interactions between Proteins and Small-Molecule Drug Candidates by Two Hydrogen-Deuterium Exchange MS-Based Methods: The Example of Apolipoprotein E3.

Wang H., Rempel D.L., Giblin D., Frieden C., and Gross M.L.
Peptide-Level Interactions between Proteins and Small-Molecule Drug Candidates by Two Hydrogen-Deuterium Exchange MS-Based Methods: The Example of Apolipoprotein E3.
Analytical Chem. doi: 10.1021/acs.analchem.7b01121. (2017) (Abstract)

Congratulations to Drake Jensen for being selected for the 2017 Elson Fellowship in honor of Dr. Elliot Elson

Mr. Drake Jensen received his B.A. in Chemistry and B.S. in Biology from Southern Illinois University Edwardsville in 2013. During this time, he began pursuing research in equilibrium and kinetic studies of Calmodulin target recognition. After graduation he continued research in the same lab and completed a M.S. in Chemistry in 2015. He joined the Division of Biological and Biomedical Sciences at Washington University the same year as part of the Computational & Molecular Biophysics program. (more…)

Eclipse Party – 2017

On Monday, August 21st, 2017, Jayma invited members of the BMB Department out to her house to get a good view the total eclipse of the sun.

Click on the following to view more photos or a slideshow of the photos taken at the event.

Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.

Kunkel T.A. and Burgers P.M.
Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.
Bioessays. 39(8). (2017) (Abstract)

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.

Albert B.J., Niu A., Ramani R., Marshall G.R., Wender P.A., Williams R.M., Ratner L., Barnes A.B., and Kyei G.B.
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.
Sci Rep. 7(1):7456. (2017) (Abstract)