Category: Greenberg, M. Publications

Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease.

Barrick S.K., Clippinger S.R., Greenberg L., & Greenberg M.J. (2019). “Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease.” Biophys J. 2019 May 7. pii: S0006-3495(19)30379-0. doi: 10.1016/j.bpj.2019.05.002. [Epub ahead of print] (Abstract)

Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling.

Porter J.R., Moeder K.E., Sibbald C.A., Zimmerman M.I., Hart K.M., Greenberg M.J., & Bowman G.R. (2019). “Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling.” Biophys J. 2019 Mar 5;116(5):818-830. doi: 10.1016/j.bpj.2018.11.3144. Epub 2019 Jan 25. (Abstract)

A Familial Dilated Cardiomyopathy Mutation Decreases Myosin Generated Tension at the Molecular Level and Alters Mechanosensing at the Cellular Level

Sarah R. Clippinger, Paige E. Cloonan, Lina Greenberg, William Stump, & Michael J. Greenberg. (2019). “A Familial Dilated Cardiomyopathy Mutation Decreases Myosin Generated Tension at the Molecular Level and Alters Mechanosensing at the Cellular Level” Biophysical Journal. Volume 116, Issue 3, Supplement 1, 15 February 2019, Page 30a. (Abstract)

Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke.

Woody M.S., Greenberg M.J., Barua B., Winkelmann D.A., Goldman Y.E., & Ostap E.M. (2018). “Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke.” Nat Commun. 2018 Sep 21;9(1):3838. doi: 10.1038/s41467-018-06193-2. (Abstract)

Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery.

Greenberg M.J., Daily N.J., Wang A., Conway M.K., & Wakatsuki T. (2018). “Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery.” Front Cardiovasc Med. 2018 Sep 19;5:120. doi: 10.3389/fcvm.2018.00120. eCollection 2018. (Abstract)

Cooperative changes in solvent exposure identify cryptic pockets, conformational switches, and allosteric coupling

Justin R Porter, Katelyn E Moeder, Carrie A Sibbald, Maxwell I Zimmerman, Kathryn M Hart, Michael J Greenberg, & Gregory R Bowman (2018). “Cooperative changes in solvent exposure identify cryptic pockets, conformational switches, and allosteric coupling” bioRxiv. September 18, 2018. doi.org/10.1101/323568. (Abstract)

Single Molecule, Optical Trapping Studies of Omecamtiv Mercarbil on Human Cardiac Myosin’s Force Production

Michael S. Woody, Michael J. Greenberg, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, & E. Michael Ostap (2018). “Single Molecule, Optical Trapping Studies of Omecamtiv Mercarbil on Human Cardiac Myosin’s Force Production” Biophysical Journal, Volume 114, Issue 3, Supplement 1, 2 February 2018, Pages 317a-318a. doi.org/10.1016/j.bpj.2017.11.1787 (Abstract)