Targeting multiple enzymes in vitamin K metabolism for anticoagulation
Weikai Li (2021). “Targeting multiple enzymes in vitamin K metabolism for anticoagulation” J Thromb Haemost. 2021 Mar;19(3):633-636. doi: 10.1111/jth.15212. (Abstract)
Category: Li Publications
Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation
Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M. Krezel, & Weikai Li (2021). “Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation” Science. 2021 Jan 1;371(6524):eabc5667. doi: 10.1126/science.abc5667. Epub 2020 Nov 5. (Abstract)
Integral Membrane Enzymes (2020)
Weikai Li, Russell E. Bishop, & Filippo Mancia. (2020). “Integral Membrane Enzymes (2020)” J Mol Biol. 2020 Aug 21;432(18):4943-4945. doi: 10.1016/j.jmb.2020.07.022. Epub 2020 Jul 30. (Abstract)
Open conformation of tetraspanins shapes interaction partner networks on cell membranes
Yihu Yang, Xiaoran Roger Liu, Zev J. Greenberg, Fengbo Zhou, Peng He, Lingling Fan, Shixuan Liu, Guomin Shen, Takeshi Egawa, Michael L. Gross, Laura G. Schuettpelz, & Weikai Li (2020). “Open conformation of tetraspanins shapes interaction partner networks on cell membranes” EMBO J (2020) e105246. 2020-08-16. doi: 10.15252/embj.2020105246. (Abstract)
Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay
Wenwen Gao, Yaqi Xu, Hongli Liu, Meng Gao, Qing Cao, Yiyi Wang, Longteng Cui, Rong Huang, Yan Shen, Sanqiang Li, Haiping Yang, Yixiang Chen, Chaokun Li, Haichuan Yu, Weikai Li, & Guomin Shen. (2020). “Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay” Blood Adv. 2020 Aug 11;4(15):3659-3667. doi: 10.1182/bloodadvances.2020002520. (Abstract)
Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy
Shuang Li, Shixuan Liu, Xiaoran Roger Liu, Mengru Mira Zhang, and Weikai Li. (2020). “Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy” Blood Adv. 2020 May 26; 4(10): 2202–2212. Published online 2020 May 20. doi: 10.1182/bloodadvances.2020001750 (Abstract)
Characterization of Warfarin Inhibition Kinetics Requires Stabilization of Intramembrane Vitamin K Epoxide Reductases
Shuang Li, Shixuan Liu, Yihu Yang, & Weikai Li (2020). “Characterization of Warfarin Inhibition Kinetics Requires Stabilization of Intramembrane Vitamin K Epoxide Reductases” J Mol Biol. 2020 May 20;S0022-2836(20)30350-8. doi: 10.1016/j.jmb.2020.05.009. Online ahead of print. (Abstract)
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Zev J. Greenberg, Darlene A. Monlish, Rachel L. Bartnett, Yihu Yang, Guomin Shen, Weikai Li, Jeffrey J. Bednarski, & Laura G. Schuettpelz. (2020). “The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.” J Immunol. 2020 Jan 1;204(1):58-67. doi: 10.4049/jimmunol.1900539. Epub 2019 Nov 20. (Abstract)
Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.
Yang Z., Yan H., Dai W., Jing J., Yang Y., Mahajan S., Zhou Y., Li W., Macaubas C., Mellins E.D., Shih C.C., Fitzpatrick J.A.J., & Faccio R. (2019). “Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.” J Autoimmun. 2019 Jul;101:94-108. doi: 10.1016/j.jaut.2019.04.015. Epub 2019 Apr 22. (Abstract)
Structure of the monotopic membrane protein (S)-mandelate dehydrogenase at 2.2Å resolution.
Sukumar N., Liu S., Li W., Mathews F.S., Mitra B., & Kandavelu P. (2018). “Structure of the monotopic membrane protein (S)-mandelate dehydrogenase at 2.2Å resolution.” Biochimie. 2018 Jul 30. pii: S0300-9084(18)30212-8. doi: 10.1016/j.biochi.2018.07.017. (Abstract)