Author: Nicholas Caito

Maxwell Zimmerman Awarded Pharmacology Prize

Maxwell ZimmermanCongratulations to Maxwell Zimmerman for being awarded the Dr. Philip Needleman Pharmacology Prize.

The award is presented annually from the Department of Developmental Biology to a graduating student demonstrating outstanding achievements it the field of Pharmacology. Maxwell is a PhD student in the Computational and Molecular Biophysics Program – he is completing his thesis research in the lab of Dr. Gregory Bowman. (more…)

Protein Environment and DNA Orientation Affect Protein-Induced Cy3 Fluorescence Enhancement.

Nguyen B., Ciuba M.A., Kozlov A.G., Levitus M., & Lohman T.M. (2019). “Protein Environment and DNA Orientation Affect Protein-Induced Cy3 Fluorescence Enhancement.” Biophys J. 2019 Jun 7. pii: S0006-3495(19)30448-5. doi: 10.1016/j.bpj.2019.05.026. [Epub ahead of print] (Abstract)

CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase.

Jensen D., Ruiz Manzano A., Rammohan J., Stallings C.L., & Galburt E.A. (2019). “CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase.” Nucleic Acids Res. 2019 May 25. pii: gkz449. doi: 10.1093/nar/gkz449. [Epub ahead of print] (Abstract)

Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA, but no DNA ends.

Sarem Hailemariam, Sandeep Kumar, & Peter M. Burgers (2019). “Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA, but no DNA ends.” J Biol Chem. 2019 Jun 28;294(26):10120-10130. doi: 10.1074/jbc.RA119.008410. Epub 2019 May 9. (Abstract)

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.

Heitmeier M.R., Hresko R.C., Edwards R.L., Prinsen M.J., Ilagan M.X.G., Odom John A.R, & Hruz P.W. (2019). “Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.” PLoS One. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457. eCollection 2019. (Abstract)

Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease.

Barrick S.K., Clippinger S.R., Greenberg L., & Greenberg M.J. (2019). “Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease.” Biophys J. 2019 May 7. pii: S0006-3495(19)30379-0. doi: 10.1016/j.bpj.2019.05.002. [Epub ahead of print] (Abstract)