Author: Nicholas Caito

Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.

Harding R.J., Loppnau P., Ackloo S., Lemak A., Hutchinson A., Hunt B., Holehouse A.S., Ho J.C., Fan L., Toledo-Sherman L., Seitova A., & Arrowsmith C.H. (2019). “Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.” J Biol Chem. 2019 Apr 26;294(17):6986-7001. doi: 10.1074/jbc.RA118.007204. Epub 2019 Mar 6. (Abstract)

Josh Rackers selected as the 2019 Ceil M. DeGutis Prize Fellow

Josh Rackers

Josh Rackers is a graduate student in Biophysics at Washington University in St. Louis. His work focuses on using the tools of applied quantum mechanics to predict the behavior and interactions of biological molecules. This work is motivated by a deeply held belief that physics holds the answers to many of biology’s most important problems. Josh obtained a bachelor’s degree in Physics and Political Science from The Ohio State University. While at Ohio State, he performed research on Positron Emission Tomography (PET) silicon-based detector design. Following graduation, Josh decided that the most immediate way to make an impact on the world was to become a teacher. He was selected for Teach For America, an organization that places top university graduates in teaching positions at poor, mostly-urban schools. He taught high school physics and chemistry in Baltimore, Maryland in what was certainly the most difficult and rewarding job of his career. He claims to have succeeded in persuading a generation of students that physics really does matter to the real world. (more…)

Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.

Yang Z., Yan H., Dai W., Jing J., Yang Y., Mahajan S., Zhou Y., Li W., Macaubas C., Mellins E.D., Shih C.C., Fitzpatrick J.A.J., & Faccio R. (2019). “Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.” J Autoimmun. 2019 Jul;101:94-108. doi: 10.1016/j.jaut.2019.04.015. Epub 2019 Apr 22. (Abstract)