Author: Conrad Weiland

Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B

Meng Gao, Long Chen, Jinlong Yang, Shixia Dong, Qing Cao, Zihan Cui, Yanyan Dong, Hongli Liu, Yan Shen, Haiping Yang, Zhenyu Hao, Lei Zhang, Weikai Li, Jian-Ke Tie & Guomin Shen (2024). “Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B” Blood Adv.2024 Aug 13;8(15):3893-3905. doi: 10.1182/bloodadvances.2023012432. (Abstract)

Congratulations to Jin Ye being awarded the 2024 BMB Postdoctoral Research Discovery and Innovation Award!

Jin Ye Dr. Jin Ye is a postdoctoral associate in the laboratory of Dr. Weikai Li in the Department of Biochemistry and Molecular Biophysics at Washington University in St. Louis. Dr. Ye received a B.A. in Biotechnology from Northeast Agricultural University and a Ph.D. in Biochemistry and Molecular Biology from University of Science and Technology of China, where his work focused on the mechanistic and functional studies of Ankyrin-G mediated protein complex in neuronal polarity maintenance and signal transmission.

During his postdoctoral training at the Li lab, his work mainly focuses on structural and mechanistic studies of vesicular neurotransmitter transporters. (more…)

Congratulations to Brent Scott being awarded the 2024 BMB Postdoctoral Research Discovery and Innovation Award!

Scott Dr. Brent Scott is a second-year postdoc in the laboratory of Dr. Michael Greenberg and is currently funded by the Pediatric Cardiovascular and Pulmonary Disease Training Program. Dr. Scott received his B.S. in Exercise Science with a minor in Sports Medicine from Belmont University (Nashville, TN) and was a research assistant for Dr. Ted Towse in the Neuromuscular Physiology Laboratory at Vanderbilt University Medical Center. He then received both an M.S. and Ph.D. in Kinesiology from the University of Massachusetts Amherst working in the Muscle Biophysics Laboratory of Dr. Ned Debold where he studied the basis of energy transduction by myosin and the molecular mechanisms underlying skeletal muscle fatigue. (more…)

Congratulations to Melissa Arenz for being awarded the 2024 Jayma Mikes Departmental Service Award!

Melissa Arenz Mrs. Arenz was publicly recognized of this well-deserved award on May 20th, 2024 at the BMB Departmental Retreat.

Mrs. Arenz was nominated by Dr. Michael Greenberg for her unwavering dedication to departmental activities and focus on cultivating a positive and supportive environment. With her attention to detail, empathetic leadership, meticulous organizational skills, and vast knowledge of the university. (more…)

Targeting a transcriptional co-repressor to prevent photoreceptor degeneration

January 1st, 2024 – Alex Holehouse, PhD Assistant Professor in the Department of Biochemistry and Molecular Biophysics, along with Joe Corbo, MD, PhD, in the Department of Pathology and Immunology, received a new two-year grant award from the Hope Center entitled “Targeting a transcriptional co-repressor to prevent photoreceptor degeneration.”

Uncovering the regulatory logic of gene expression encoded by disordered regions

September 1st, 2023 – Alex Holehouse, PhD, Assistant Professor in the Department of Biochemistry and Molecular Biophysics, received a 2023 NIH New Innovator Award. This five-year award from the National Institute of Health, administered through the National Cancer Institute, is entitled “Uncovering the regulatory logic of gene expression encoded by disordered regions.”.

Spotlight on Research – Holehouse Lab


The Holehouse Lab works to understand how intrinsically disordered regions – protein regions that lack a stable 3D structure – facilitate molecular and cellular function. The lab combines computational and experimental approaches to elucidate how disordered regions behave in isolation, how they interact with partners, how they evolve, and how mutations in disordered regions impact their normal cellular function in the context of human disease. The lab explores these questions in various contexts, combining synthetic biology and protein design to decode the underlying principles that relate sequence to function.

Spotlight on Research – Egervari Lab


The Egervari Lab’s goal is to elucidate how metabolic changes influence gene expression in the brain in physiological and pathological states. We combine state-of-the art proteomic, genomic and metabolomic approaches including on the single cell level, with quantitative and mechanistic studies, using disease-relevant in vitro and in vivo models. Our hope is that this work will identify new therapeutic targets for a variety of human diseases, and transform our understanding of how the brain adapts to environmental stimuli.