Department of Biochemistry and Molecular Biophysics

Author: Conrad Weiland

2024 News / All News

Congratulations to Daniel Ramirez for receiving the 2024 ORISE Intelligence Community Postdoctoral Research Fellowship!

Daniel Dr. Ramirez was awarded the Oak Ridge Institute for Science and Education (ORISE) Intelligence Community Postdoctoral Research Fellowship for his project entitled “Mass spectrometry profiling of biomolecular condensate proteins and their regulation by glucose metabolism and posttranslational O-GlcNAc modification”. This is a 2-year fellowship funded primarily by the Office of the Director of National Intelligence (ODNI) and the U.S. Department of Energy that provides a stipend, health insurance supplement, travel allowance, and a lab supply budget.

All Publications / Goo Publications

Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library

Abhay K Singh, Calvin D Lewis, Cristian A W V Boas, Philipp Diebolder, Prashant N Jethva, Aaron Rhee, Jong Hee Song, Young Ah Goo, Shunqian Li, Michael L Nickels, Yongjian Liu, Buck E Rogers, Vaishali Kapoor & Dennis E Hallahan (2024). “Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library” Clin Cancer Res. 2024 Apr 1;30(7):1293-1306. doi: 10.1158/1078-0432.CCR-23-3647. (Abstract)

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Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring

Tusar Giri, Susan E Maloney, Saswat Giri, Young Ah Goo, Jong Hee Song, Minsoo Son, Eric Tycksen, Sara B Conyers, Annie Bice, Xia Ge, Joel R Garbow, James D Quirk, Adam Q Bauer & Arvind Palanisamy (2024). “Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring” iScience. 2024 Jan 22;27(2):108960. doi: 10.1016/j.isci.2024.108960. eCollection 2024 Feb 16. (Abstract)

All Publications / Holehouse Publications

Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator

Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse & Jennifer M Hurley (2024). “Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator” Nat Communn. 2024 Apr 25;15(1):3523. doi: 10.1038/s41467-024-47761-z. (Abstract)

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Phase transition of GvpU regulates gas vesicle clustering in bacteria

Zongru Li, Qionghua Shen, Emery T Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai & George J Lu (2024). “Phase transition of GvpU regulates gas vesicle clustering in bacteria” Nat Microbiol. 2024 Apr;9(4):1021-1035. doi: 10.1038/s41564-024-01648-3. Epub 2024 Mar 29. (Abstract)

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Labile assembly of a tardigrade protein induces biostasis

S Sanchez-Martinez, K Nguyen, S Biswas, V Nicholson, A V Romanyuk, J Ramirez, S Kc, A Akter, C Childs, E K Meese, E T Usher, G M Ginell, F Yu, E Gollub, M Malferrari, F Francia, G Venturoli, E W Martin, F Caporaletti, G Giubertoni, S Woutersen, S Sukenik, D N Woolfson, A S Holehouse & T C Boothby (2024). “Labile assembly of a tardigrade protein induces biostasis” Protein Sci.2024 Apr;33(4):e4941. doi: 10.1002/pro.4941. (Abstract)

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Structural biases in disordered proteins are prevalent in the cell

David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse & Shahar Sukenik (2024). “Structural biases in disordered proteins are prevalent in the cell” Nat Struct Mol Biol. 2024 Feb;31(2):283-292. doi: 10.1038/s41594-023-01148-8. Epub 2024 Jan 4. (Abstract)