Author: Conrad Weiland

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

Jiyeon Lee, Julie M Dimitry, Jong Hee Song, Minsoo Son, Patrick W Sheehan, Melvin W King, G Travis Tabor, Young Ah Goo, Mitchell A Lazar, Leonard Petrucelli, Erik S Musiek (2023). “Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice” Nat Commun. 2023 Aug 25;14(1):5197. doi: 10.1038/s41467-023-40927-1. (Abstract)

Spotlight on Research – Goo Lab


Young Ah Goo’s lab specializes in using mass spectrometry-based multi-omics to address biological questions, particularly the discovery of diagnostic and prognostic biomarkers and therapeutic targets for human diseases. She directs The Mass Spectrometry Technology Access Center, which supports advanced technologies in proteomics, metabolomics, lipidomics, and mass spectrometry imaging.

Congratulations to Daniel Ramirez for receiving the 2024 ORISE Intelligence Community Postdoctoral Research Fellowship!

Daniel Dr. Ramirez was awarded the Oak Ridge Institute for Science and Education (ORISE) Intelligence Community Postdoctoral Research Fellowship for his project entitled “Mass spectrometry profiling of biomolecular condensate proteins and their regulation by glucose metabolism and posttranslational O-GlcNAc modification”. This is a 2-year fellowship funded primarily by the Office of the Director of National Intelligence (ODNI) and the U.S. Department of Energy that provides a stipend, health insurance supplement, travel allowance, and a lab supply budget.

Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library

Abhay K Singh, Calvin D Lewis, Cristian A W V Boas, Philipp Diebolder, Prashant N Jethva, Aaron Rhee, Jong Hee Song, Young Ah Goo, Shunqian Li, Michael L Nickels, Yongjian Liu, Buck E Rogers, Vaishali Kapoor & Dennis E Hallahan (2024). “Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library” Clin Cancer Res. 2024 Apr 1;30(7):1293-1306. doi: 10.1158/1078-0432.CCR-23-3647. (Abstract)

Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring

Tusar Giri, Susan E Maloney, Saswat Giri, Young Ah Goo, Jong Hee Song, Minsoo Son, Eric Tycksen, Sara B Conyers, Annie Bice, Xia Ge, Joel R Garbow, James D Quirk, Adam Q Bauer & Arvind Palanisamy (2024). “Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring” iScience. 2024 Jan 22;27(2):108960. doi: 10.1016/j.isci.2024.108960. eCollection 2024 Feb 16. (Abstract)

Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator

Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse & Jennifer M Hurley (2024). “Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator” Nat Communn. 2024 Apr 25;15(1):3523. doi: 10.1038/s41467-024-47761-z. (Abstract)

Phase transition of GvpU regulates gas vesicle clustering in bacteria

Zongru Li, Qionghua Shen, Emery T Usher, Andrew P Anderson, Manuel Iburg, Richard Lin, Brandon Zimmer, Matthew D Meyer, Alex S Holehouse, Lingchong You, Ashutosh Chilkoti, Yifan Dai & George J Lu (2024). “Phase transition of GvpU regulates gas vesicle clustering in bacteria” Nat Microbiol. 2024 Apr;9(4):1021-1035. doi: 10.1038/s41564-024-01648-3. Epub 2024 Mar 29. (Abstract)

Labile assembly of a tardigrade protein induces biostasis

S Sanchez-Martinez, K Nguyen, S Biswas, V Nicholson, A V Romanyuk, J Ramirez, S Kc, A Akter, C Childs, E K Meese, E T Usher, G M Ginell, F Yu, E Gollub, M Malferrari, F Francia, G Venturoli, E W Martin, F Caporaletti, G Giubertoni, S Woutersen, S Sukenik, D N Woolfson, A S Holehouse & T C Boothby (2024). “Labile assembly of a tardigrade protein induces biostasis” Protein Sci.2024 Apr;33(4):e4941. doi: 10.1002/pro.4941. (Abstract)