Author: Liam Savage

Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections

Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections.

Banas V, Elfawal MA, Rosa BA, Mahoney M, Kauffman J, Goetz E, Chen P, Aroian RV, Mitreva M, Janetka JW.

ACS Infect Dis. 2025 Jan 19. doi: 10.1021/acsinfecdis.4c00864. Online ahead of print.
PMID: 39828994

DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion.

Das M, Hile SE, Brewster J, Boer JL, Bezalel-Buch R, Guo Q, Yang W, Burgers PM, Eckert KA, Freudenreich CH. “DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion. ” Nucleic Acids Res. 2024 Dec 27:gkae1254. doi: 10.1093/nar/gkae1254. Online ahead of print. PMID: 39727171(Abstract)

Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease.

Walker EC, Javati S, Todd EM, Matlam JP, Lin X, Bryant M, Krone E, Ramani R, Chandra P, Green TP, Anaya EP, Zhou JY, Alexander KA, Tong RS, Yuasi L, Boluarte S, Yang F, Greenberg L, Nerbonne JM, Greenberg MJ, Clemens RA, Philips JA, Wilson LD, Halabi CM, DeBosch BJ, Blyth CC, Druley TE, Kazura JW, Pomat WS, Morley SC. “Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease.” Nat Immunol. 2024 Dec;25(12):2247-2258. doi: 10.1038/s41590-024-01998-4. Epub 2024 Nov 4. PMID: 39496954 (Abstract)

A roadmap to cysteine specific labeling of membrane proteins for single-molecule photobleaching studies

Ernst M, Mahoney-Kruszka R, Zelt NB, Robertson JL. “A roadmap to cysteine specific labeling of membrane proteins for single-molecule photobleaching studies.” Methods. 2024 Nov 23;234:21-35. doi: 10.1016/j.ymeth.2024.10.013. Epub ahead of print. PMID: 39586432.(Abstract)

Congratulations to Janice L. Robertson on Receiving the 2025 Agnes Pockels Award in Lipids and Membrane Biophysics

Robertson is being honored for her work advancing the experimental and computational study of membrane protein oligomerization in membranes, including identifying critical driving forces and regulation of stability by ions and lipids.

 

For more information, click here.

Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B.

Gao M, Chen L, Yang J, Dong S, Cao Q, Cui Z, Dong Y, Liu H, Shen Y, Yang H, Hao Z, Zhang L, Li W, Tie JK, Shen G. “Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B”. Blood Adv. 2024 Aug 13;8(15):3893-3905. doi: 10.1182/bloodadvances.2023012432. PMID: 38820490