Category: Janetka Publications

Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.

Kostakioti M., Hadjifrangiskou M., Cusumano C.K., Hannan T.J., Janetka J.W., & Hultgren S.J. (2012). “Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.” Infect Immun. 2012 Aug;80(8):2826-34. doi: 10.1128/IAI.00283-12. Epub 2012 Jun 4. (Abstract)

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

Han Z., Pinkner J.S., Ford B., Chorell E., Crowley J.M., Cusumano C.K., Campbell S., Henderson J.P., Hultgren S.J., and Janetka J.W. (2012) “Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.” J Med Chem. 2012 Apr 26;55(8):3945-59. doi: 10.1021/jm300165m. Epub 2012 Apr 13. (Abstract)

Treatment and prevention of urinary tract infection with orally active FimH inhibitors.

Cusumano C.K., Pinkner J.S., Han Z., Greene S.E., Ford B.A., Crowley J.R., Henderson J.P., Janetka J.W., and Hultgren S.J.
Treatment and prevention of urinary tract infection with orally active FimH inhibitors.
Sci Transl Med. 3(109):109ra115. doi: 10.1126/scitranslmed.3003021. (2011) (Abstract)

Discovery of a novel class of triazolones as checkpoint kinase inhibitors–hit to lead exploration.

Oza V., Ashwell S., Brassil P., Breed J., Deng C., Ezhuthachan J., Haye H., Horn C., Janetka J., Lyne P., Newcombe N., Otterbien L., Pass M., Read J., Roswell S., Su M., Toader D., Yu D., Yu Y., Valentine A., Webborn P., White A., Zabludoff S., and Zheng X.
Discovery of a novel class of triazolones as checkpoint kinase inhibitors–hit to lead exploration.
Bioorg Med Chem Lett. 20(17):5133-8. doi: 10.1016/j.bmcl.2010.07.015. (2010) (Abstract)

Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

Han, Z., Pinkner, J.S., Ford, B., Obermann, R., Nolan, W., Wildman, S.A., Hobbs, D., Ellenberger, T., Cusumano, C.K., Hultgren, S.J. and Janetka, J.W.
Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
J Med Chem. 53(12):4779-92. doi: 10.1021/jm100438s. (2010) (Abstract)