The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not play a role in the localization of the receptor to lipid rafts.
Macdonald J., Li Z., Su W., & Pike L.J. (2006). “The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not play a role in the localization of the receptor to lipid rafts.” Biochim Biophys Acta. 2006 Aug;1763(8):870-8. Epub 2006 May 13. (Abstract)