Author: Nicholas Caito

2017 News / All News

Nov 17th, 2017

Michael Kinch – Cutting NIH budget could cripple drug development

Michael Kinch A proposal to slash funding for the National Institutes of Health (NIH) could severely impair the development of new, life-saving drugs, according to a new analysis by researchers at Washington University School of Medicine in St. Louis.

NIH funding supports the early research needed to develop new, innovative drugs. President Donald Trump’s proposed budget calls for cutting the NIH budget by 21 percent, or about $7.2 billion. (more…)

All Publications / Bowman Publications

Nov 16th, 2017

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.

Halstead A.M., Kapadia C.D., Bolzenius J., Chu C.E., Schriefer A., Wartman L.D., Bowman G.R., & Arora V.K. (2017). “Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation.” Elife. 2017 Nov 16;6. pii: e30862. doi: 10.7554/eLife.30862. (Abstract)

All Publications / Kinch Publications

Nov 16th, 2017

NIH Support for FDA-Approved Medicines.

Griesenauer R.H., Moore R., & Kinch M.S. (2017). “NIH Support for FDA-Approved Medicines.” Cell Chem Biol. 2017 Nov 16;24(11):1315-1316. doi: 10.1016/j.chembiol.2017.11.002. (Abstract)

All Publications / Lohman Publications

Nov 14th, 2017

Large domain movements upon UvrD dimerization and helicase activation.

Nguyen B., Ordabayev Y., Sokoloski J.E., Weiland E., & Lohman T.M. (2017). “Large domain movements upon UvrD dimerization and helicase activation.” Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12178-12183. doi: 10.1073/pnas.1712882114. Epub 2017 Oct 30. (Abstract)

2017 BMB Seminars / All Seminars / BMB Seminars

Nov 13th, 2017

Non-equilibrium regulation of DNA transcription

2017-11-14 – Jeff Gelles, Ph.D. – Brandeis University – “Non-equilibrium regulation of DNA transcription” (more…)

All Publications / Li Publications

Nov 7th, 2017

Intramembrane thiol oxidoreductases: evolutionary convergence and structural controversy.

Li S., Shen G., & Li W. (2017). “Intramembrane thiol oxidoreductases: evolutionary convergence and structural controversy.” Biochemistry. 2018 Jan 23;57(3):258-266. doi: 10.1021/acs.biochem.7b00876. Epub 2017 Nov 7. (Abstract)

All Publications / Galburt Publications

Nov 6th, 2017

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning.

Tomko E.J., Fishburn J., Hahn S., & Galburt E.A. (2017). “TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning.” Nat Struct Mol Biol. 2017 Dec;24(12):1139-1145. doi: 10.1038/nsmb.3500. Epub 2017 Nov 6. (Abstract)

2017 BMB Seminars / All Seminars / BMB Seminars

Nov 6th, 2017

Measuring Biochemistry with Biophysics: Watching How Single Molecules Work Together Inside Living Bacteria Cells

2017-11-07 – Julie Biteen, Ph.D. – University of Michigan – “Measuring Biochemistry with Biophysics: Watching How Single Molecules Work Together Inside Living Bacteria Cells” (more…)

All Publications / Bowman Publications

Oct 31st, 2017

Endogenous retinoid X receptor ligands in mouse hematopoietic cells.

Niu H., Fujiwara H., di Martino O., Hadwiger G., Frederick T.E., Menéndez-Gutiérrez M.P., Ricote M., Bowman G.R., & Welch J.S. (2017). “Endogenous retinoid X receptor ligands in mouse hematopoietic cells.” Sci Signal. 2017 Oct 31;10(503). pii: eaan1011. doi: 10.1126/scisignal.aan1011. (Abstract)

All Publications / Bowman Publications

Oct 31st, 2017

Mechanistic Basis for ATP-Dependent Inhibition of Glutamine Synthetase by Tabtoxinine-β-lactam.

Patrick G.J., Fang L., Schaefer J., Singh S., Bowman G.R., & Wencewicz T.A. (2017). “Mechanistic Basis for ATP-Dependent Inhibition of Glutamine Synthetase by Tabtoxinine-β-lactam.” Biochemistry. 2018 Jan 9;57(1):117-135. doi: 10.1021/acs.biochem.7b00838. Epub 2017 Oct 31. (Abstract)