Hart K.M., Moeder K.E., Ho C.M.W., Zimmerman M.I., Frederick T.E., & Bowman G.R. (2017). “Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators.” PLoS One. 2017 Jun 1;12(6):e0178678. doi: 10.1371/journal.pone.0178678. eCollection 2017. (Abstract)
Frieden C., Wang H., & Ho C.M.W. (2017). “A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions.” Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6292-6297. doi: 10.1073/pnas.1705080114. Epub 2017 May 30. (Abstract)
Wang H., Shu Q., Frieden C., & Gross M.L. (2017). “Deamidation slows Curli Amyloid-Protein Aggregation.” Biochemistry. 2017 Jun 13;56(23):2865-2872. doi: 10.1021/acs.biochem.7b00241. Epub 2017 May 26. (Abstract)
On May 5th, 2017, Whitney Grither was awarded the 2017 Ceil M. DeGutis Prize in Chemical Biology/Medicinal Chemistry. Whitney presented her research entitled: Selective Small Molecule Inhibition of Discoidin Domain Receptor 2. Whitney graduated this Spring from the Biochemistry graduate program. She finished her PhD work in the laboratory of Dr. Greg Longmore with the express purpose of identifying novel modes of inhibiting an underappreciated collagen receptor, DDR2, which they had just shown was critical for breast cancer metastasis in experimental mouse models and humans (Nature Cell Biology, 2013). (more…)
Mydock-McGrane L.K., Hannan T.J., & Janetka J.W. (2017). “Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn’s disease.” Expert Opin Drug Discov. 2017 Jul;12(7):711-731. doi: 10.1080/17460441.2017.1331216. Epub 2017 Jun 2. (Abstract)
2017-05-02 – Eric Galburt, Ph.D. – Washington University in Saint Louis – “Biophysics of Transcription Initiation” (more…)
On April 21st, 2017, we held our 3rd Annual Chili Cook-off. This year included a few non-chili options such as vegan and Chinese selections. The Burgers Lab won this year. Congratulations!
Click on the following to view more photos or a slideshow of the photos taken at the event.
2017-04-25 – Martin Gruebele, Ph.D. – University of Illinois Urbana-Champaign – “Folding: from in silico to in vitro to in-cell” (more…)
Owusu B.Y., Galemmo R., Janetka J., & Klampfer L. (2017). “Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment.” Cancers (Basel). 2017 Apr 17;9(4). pii: E35. doi: 10.3390/cancers9040035. (Abstract)
2017-04-18 – Jean Schaffer, M.D. – Washington University in Saint Louis – “Small RNA Regulators of Metabolic Stress” (more…)