Author: Nicholas Caito

14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.

Chen X., Kim I.K., Honaker Y., Paudval S.C., Koh W.K., Sparks M., Lis S., Piwnica-Worms H., Ellenberger T., & You Z. (2015). “14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. J Biol Chem. 2015 May 8;290(19):12300-12. doi: 10.1074/jbc.M115.644005. Epub 2015 Apr 1. (Abstract)

Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.

Franco F.M., Jones D.E., Harris P.K., Han Z., Wildman S.A., Jarvis C.M., & Janetka J.W. (2015). “Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.” Bioorg Med Chem. 2015 May 15;23(10):2328-43. doi: 10.1016/j.bmc.2015.03.072. Epub 2015 Apr 4. (Abstract)

High-resolution crystal structures of protein helices reconciled with three-centered hydrogen bonds and multipole electrostatics.

Kuster D.J., Liu C., Ponder J.W., & Marshall G.R. (2015). “High-resolution crystal structures of protein helices reconciled with three-centered hydrogen bonds and multipole electrostatics.” PLoS One. 2015 Apr 20;10(4):e0123146. doi: 10.1371/journal.pone.0123146. eCollection 2015. (Abstract)

Protein structure. Direct observation of structure-function relationship in a nucleic acid-processing enzyme.

Comstock M.J., Whitley K.D., Jia H., Sokoloski J., Lohman T.M., Ha T., & Chemla Y.R. (2015). “Protein structure. Direct observation of structure-function relationship in a nucleic acid-processing enzyme.” Science. 2015 Apr 17;348(6232):352-4. doi: 10.1126/science.aaa0130. Epub 2015 Apr 16. (Abstract)