Author: Nicholas Caito

Plasmodium falciparum SSB tetramer wraps single-stranded DNA with similar topology but opposite polarity to E. coli SSB.

Antony E., Weiland E.A., Korolev S., & Lohman T.M. (2012). “Plasmodium falciparum SSB tetramer wraps single-stranded DNA with similar topology but opposite polarity to E. coli SSB.” J Mol Biol. 2012 Jul 20;420(4-5):269-83. doi: 10.1016/j.jmb.2012.04.021. Epub 2012 Apr 27. (Abstract)

Plasmodium falciparum SSB tetramer binds single-stranded DNA only in a fully wrapped mode.

Antony E., Kozlov A.G., Nguyen B., & Lohman T.M. (2012). “Plasmodium falciparum SSB tetramer binds single-stranded DNA only in a fully wrapped mode.” J Mol Biol. 2012 Jul 20;420(4-5):284-95. doi: 10.1016/j.jmb.2012.04.022. Epub 2012 Apr 26. (Abstract)

Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.

Yang B., Hird A.W., Russell D.J., Fauber B.P., Dakin L.A., Zheng X., Su Q., Godin R., Brassil P., Devereaux E., and Janetka J.W. (2012) “Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.” Bioorg Med Chem Lett. 2012 Jul 15;22(14):4907-11. doi: 10.1016/j.bmcl.2012.04.104. Epub 2012 Apr 30. (Abstract)

Slow Unfolded-State Structuring in Acyl-CoA Binding Protein Folding Revealed by Simulation and Experiment

Voelz, V.A., Jager, M., Yao, S., Chen, Y., Zhu, L., Waldauer, S.A., Bowman, G.R., Friedrichs, M., Bakajin, O., Lapidus, L.J., Weiss, S., and Pande, V.S.
Slow Unfolded-State Structuring in Acyl-CoA Binding Protein Folding Revealed by Simulation and Experiment
J Am Chem Soc 134:12565-12577. (2012). (Abstract)

Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.

Guiton P.S., Cusumano C.K., Kline K.A., Dodson K.W., Han Z., Janetka J.W., Henderson J.P., Caparon M.G., & Hultgren S.J. (2012). “Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.” Antimicrob Agents Chemother. 2012 Sep;56(9):4738-45. doi: 10.1128/AAC.00447-12. Epub 2012 Jun 25.

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

Oza V., Ashwell S., Almeida L., Brassil P., Breed J., Deng C., Gero T., Grondine M., Horn C., Ioannidis S., Liu D., Lyne P., Newcombe N., Pass M., Read J., Ready S., Rowsell S., Su M., Toader D., Vasbinder M., Yu D., Yu Y., Xue Y., Zabludoff S., and Janetka J. (2012) “Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.” J Med Chem. 2012 Jun 14;55(11):5130-42. doi: 10.1021/jm300025r. Epub 2012 Jun 4. (Abstract)

Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.

Kostakioti M., Hadjifrangiskou M., Cusumano C.K., Hannan T.J., Janetka J.W., & Hultgren S.J. (2012). “Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.” Infect Immun. 2012 Aug;80(8):2826-34. doi: 10.1128/IAI.00283-12. Epub 2012 Jun 4. (Abstract)