Kim I.K., Kiefer J.R., Ho C.M., Stegeman R.A., Classen S., Tainer J.A., & Ellenberger, T. (2012). “Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.” Nat Struct Mol Biol. 2012 May 20;19(6):653-6. doi: 10.1038/nsmb.2305. (Abstract)
Frieden C. & Garai K. (2012). “Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer’s disease.” Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8913-8. doi: 10.1073/pnas.1207022109. Epub 2012 May 21. (Abstract)
Chen Z.W., Vignaud C., Jaafar A., Levy B., Gueritte F., Guenard D., Lederer F., & Mathews F.S. (2012). “High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.” Biochimie. 2012 May;94(5):1172-9. doi: 10.1016/j.biochi.2012.02.003. Epub 2012 Feb 9. (Abstract)
Levin, A.M., Bates, D.L., Ring, A.M., Krieg, C., Lin, J.T., Su, L., Moraga, I., Raeber, M.E., Bowman, G.R., Novick, P., Pande, V.S., Fathman, C.G., Boyman, O. and Garcia, K.C.
Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
Nature 484:529-533. (2012). (Abstract)
Han Z., Pinkner J.S., Ford B., Chorell E., Crowley J.M., Cusumano C.K., Campbell S., Henderson J.P., Hultgren S.J., and Janetka J.W. (2012) “Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.” J Med Chem. 2012 Apr 26;55(8):3945-59. doi: 10.1021/jm300165m. Epub 2012 Apr 13. (Abstract)
Ellenberger, T. (2012). “An arresting development in transcription.” Mol Cell. 2012 Apr 13;46(1):3-4. doi: 10.1016/j.molcel.2012.03.025. (Abstract)
Tomko E.J., Fischer C.J., & Lohman T.M. (2012). “Single-stranded DNA translocation of E. coli UvrD monomer is tightly coupled to ATP hydrolysis.” J Mol Biol. 2012 Apr 20;418(1-2):32-46. doi: 10.1016/j.jmb.2012.02.013. Epub 2012 Feb 14. (Abstract)
Shu Q., Crick S.L., Pinkner J.S., Ford B., Hultgren S.J., & Frieden C. (2012). “The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.” Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6502-7. doi: 10.1073/pnas.1204161109. Epub 2012 Apr 9. (Abstract)
Chen, C., Greenberg, M.J., Laakso, J.M., Ostap, E.M., Goldman, Y.E and Shuman, H.
Kinetic schemes for post-synchronized single molecule dynamics.
Biophys J. 102:L23-L25 (2012). (Abstract)
Tang Y.T., Gao R., Havranek J.J., Groisman E.A., Stock A.M., and Marshall G.R. (2012) “Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.” Chem Biol Drug Des. 2012 Jun;79(6):1007-17. doi: 10.1111/j.1747-0285.2012.01362.x. Epub 2012 Mar 21. (Abstract)