Category: All Publications

Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance.

Brown C.A., Hu L., Sun Z., Patel M.P., Singh S., Porter J.R., Sankaran B., Prasad B.V.V., Bowman G.R., & Palzkill T. (2020). “Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance.” J Biol Chem. 2020 Apr 16. pii: jbc.RA119.012489. doi: 10.1074/jbc.RA119.012489. [Epub ahead of print] (Abstract)

Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein

Patrick McConnell, Marlene Mekel, Alex G. Kozlov, Olivia L. Mooren, Timothy M. Lohman, & John A. Cooper (2020). “Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein” Biochemistry. 2020 Mar 24;59(11):1202-1215. doi: 10.1021/acs.biochem.0c00092. Epub 2020 Mar 10. (Abstract)

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.

Hohl M., Mojumdar A., Hailemariam S., Kuryavyi V., Ghisays F., Sorenson K., Chang M., Taylor B.S., Patel D.J., Burgers P.M., Cobb J.A., & Petrini J.H.J. (2020). “Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.” PLoS Genet. 2020 Mar 18;16(3):e1008422. doi: 10.1371/journal.pgen.1008422. [Epub ahead of print] (Abstract)

Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction

Jordan E. Ezekian, Sarah R. Clippinger, Jaquelin M. Garcia, Qixin Yang, Susan Denfield, Aamir Jeewa, William J. Dreyer, Wenxin Zou, Yuxin Fan, Hugh D. Allen, Jeffrey J. Kim, Michael J. Greenberg, & Andrew P. Landstrom (2020). “Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction” J Am Heart Assoc. 2020 Mar 3;9(5):e015111. doi: 10.1161/JAHA.119.015111. Epub 2020 Feb 26. (Abstract)

Discovery of a cryptic allosteric site in Ebola’s ‘undruggable’ VP35 protein using simulations and experiments

Matthew A. Cruz, Thomas E. Frederick, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, & Gregory R. Bowman (2020). “Discovery of a cryptic allosteric site in Ebola’s ‘undruggable’ VP35 protein using simulations and experiments” bioRxiv. doi: https://doi.org/10.1101/2020.02.09.940510 (Abstract)

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains.

Martin E.W., Holehouse A.S., Peran I., Farag M., Incicco J.J., Bremer A., Grace C.R., Soranno A., Pappu R.V., & Mittag T. (2020). “Valence and patterning of aromatic residues determine the phase behavior of prion-like domains.” Science. 2020 Feb 7;367(6478):694-699. doi: 10.1126/science.aaw8653. (Abstract)