Category: Research Awards

Single Molecule Biophysics of Intrinsically Disordered Proteins in Disease

August 23rd, 2021 – Jhullian Jamille Alston, BA, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, and the laboratories of Alex Holehouse, PhD and Andrea Soranno, PhD, received a Predoctoral to Postdoctoral Fellow Transition Award from the National Cancer Institute for his research entitled “Single Molecule Biophysics of Intrinsically Disordered Proteins in Disease”.

Collaborative Research: Functional Synergy Between Disordered Proteins and their Environment in Desiccation Protection

August 18th, 2021 – Alex Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, along with Shahar Sukenik, Assistant Professor, Department of Chemistry & Biochemistry at University of California, Merced, and Thomas Boothby, Assistant Professor, Department of Molecular Biology, University of Wyoming, received a new four year grant award from the National Science Foundation through the new “Integrative Research in Biology” mechanism for their research entitled “Collaborative Research: Functional Synergy Between Disordered Proteins and their Environment in Desiccation Protection”.

Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments

August 17th, 2021 – Matthew A Cruz, BS, Pre-Doc Trainee in the department of Biochemistry and Molecular Biophysics, and the laboratory of Gregory Bowman, PhD, received a new three-year fellowship award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases for his research entitled “Leveraging protein dynamics to drug filovirus protein-nucleic acid interactions using simulations and experiments”.

ApoE isoform-specific structure: insights on biology and pathobiology

August 17th, 2021 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, Carl Frieden, PhD, Professor of Biochemistry and Molecular Biophysics, and Rui Zhang, PhD, Assistant Professor of Biochemistry and Molecular Biophysics will collaborate in the Project named “ApoE isoform-specific structure: insights on biology and pathobiology”. The Project is part of the newly awarded five-year U19 Research Program from the National Institutes of Health, National Institute of Aging, entitled “Biology and pathobiology of apoE in aging and Alzheimer’s disease”, helmed by Dr. David Holtzman, Professor and Chair of the Department of Neurology at Washington University, in St Louis, and Dr. Guojun Bu, Professor of Medicine and Chair of the Department of Neuroscience, Mayo Clinic.

Biology and pathobiology of apoE in aging and Alzheimer’s disease

August 17th, 2021 – Greg Bowman, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Guojun Bu, Professor of Medicine and chair of the Department of Neuroscience, Mayo Clinic, received a five-year U19 Research Program – Cooperative Agreement Award from the National Institutes of Health, National Institute on Aging, entitled “Biology and pathobiology of apoE in aging and Alzheimer’s disease”. Dr. Bowman is leader of the project’s biochemical & structural biology core.

Collaborative Research: MFB: Deciphering the Logic of PTM Crosstalk via Novel Chemical Technology: Histones and Beyond

August 16th, 2021 – Benjamin Garcia, PhD, Raymond H. Wittcoff Distinguished Professor and Head of Biochemistry and Molecular Biophysics, along with Philip A Cole, MD, PhD, Professor Biological Chemistry & Molecular Pharmacology at Harvard Medical School, received a new three year grant award from The National Science Foundation for their research entitled “Collaborative Research: MFB: Deciphering the Logic of PTM Crosstalk via Novel Chemical Technology: Histones and Beyond”.

Mechanisms of DNA replication and maintenance in eukaryotes

May 14th, 2021 – Peter M. Burgers, PhD, Marvin A. Brennecke Professor of Biological Chemistry, department of biochemistry and molecular biophysics was awarded a five-year MIRA grant renewal from the National Institute of General Medical Sciences for his research entitled “Mechanisms of DNA replication and maintenance in eukaryotes”.

Intrinsic Disorder and Agonist Bias in EGF Receptor Signaling

April 15th, 2021 – Linda J. Pike, PhD, Professor of Biochemistry and Molecular Biophysics, along with Alexander S. Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics, and Gary J. Patti, PhD, Professor of Chemistry and of Genetics and Medicine, received a new four year grant award from the National Institute of General Medical Sciences for their research entitled “Intrinsic Disorder and Agonist Bias in EGF Receptor Signaling”.

Development of small molecule inhibitors of metabolic enzymes as broad-spectrum anthelmintic drugs

March 18th, 2021 – Jim Janetka, PhD, Professor of Biochemistry and Molecular Biophysics, Makedonka Mitreva, Professor of Medicine and Genetics, and Raffi Aroian, Professor of Molecular Medicine at the University of Massachusetts Medical School have received a new multi-PI R01 award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases entitled “Development of small molecule inhibitors of metabolic enzymes as broad-spectrum anthelmintic drugs”.