Author: Nicholas Caito

Reweighting of molecular simulations with explicit-solvent SAXS restraints elucidates ion-dependent RNA ensembles

Mattia Bernetti, Kathleen B. Hall, & Giovanni Bussi (2021). “Reweighting of molecular simulations with explicit-solvent SAXS restraints elucidates ion-dependent RNA ensembles” Nucleic Acids Res. 2021 Jun 9;gkab459. doi: 10.1093/nar/gkab459. Online ahead of print. (Abstract)

Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis

Ryan J. Emenecker, Alex S. Holehouse, & Lucia C. Strader (2021). “Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis” Cell Commun Signal. 2021 Jun 5;19(1):65. doi: 10.1186/s12964-021-00744-9. (Abstract)

The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ

Denis A. Kiktev, Margaret Dominska, Tony Zhang, Joseph Dahl, Elena I. Stepchenkova, Piotr Mieczkowski, Peter M. Burgers, Scott Lujan, Adam Burkholder, Thomas A. Kunkel, & Thomas D. Petes (2021). “The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ” Nucleic Acids Res. 2021 Jun 4;49(10):5623-5636. doi: 10.1093/nar/gkab371. (Abstract)

Differing biophysical properties underpin the unique signaling potentials within the plant phytochrome photoreceptor families

E. Sethe Burgie, Zachary T. K. Gannam, Katrice E. McLoughlin, Christopher D. Sherman, Alex S. Holehouse, Robert J. Stankey, & Richard D. Vierstra (2021). “Differing biophysical properties underpin the unique signaling potentials within the plant phytochrome photoreceptor families” Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2105649118. doi: 10.1073/pnas.2105649118. (Abstract)

Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins

Xiangli Wang, Yong Fu, Wandy L. Beatty, Meisheng Ma, Alan Brown, L. David Sibley, & Rui Zhang (2021). “Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins” Nat Commun. 2021 May 24;12(1):3065. doi: 10.1038/s41467-021-23351-1. (Abstract)

Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets

Michael D. Ward, Maxwell I. Zimmerman, Artur Meller, Moses Chung, S. J. Swamidass, & Gregory R. Bowman (2021). “Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets” Nat Commun. 2021 May 21;12(1):3023. doi: 10.1038/s41467-021-23246-1. (Abstract)

Garcia to head Department of Biochemistry and Molecular Biophysics

Ben GarciaBenjamin A. Garcia, PhD, a noted leader in the field of biochemistry, especially for his work advancing mass spectrometry techniques, has been named head of the Department of Biochemistry and Molecular Biophysics at Washington University School of Medicine in St. Louis. Garcia, whose appointment tentatively is set to begin July 1, also will become the Raymond H. Wittcoff Distinguished Professor. (more…)