Department of Biochemistry and Molecular Biophysics

Author: Nicholas Caito

2021 Research Awards / Bowman / Research Awards

Biology and pathobiology of apoE in aging and Alzheimer’s disease

August 17th, 2021 – Greg Bowman, PhD, Associate Professor of Biochemistry and Molecular Biophysics, along with Guojun Bu, Professor of Medicine and chair of the Department of Neuroscience, Mayo Clinic, received a five-year U19 Research Program – Cooperative Agreement Award from the National Institutes of Health, National Institute on Aging, entitled “Biology and pathobiology of apoE in aging and Alzheimer’s disease”. Dr. Bowman is leader of the project’s biochemical & structural biology core.

2021 Research Awards / Garcia / Research Awards

Collaborative Research: MFB: Deciphering the Logic of PTM Crosstalk via Novel Chemical Technology: Histones and Beyond

August 16th, 2021 – Benjamin Garcia, PhD, Raymond H. Wittcoff Distinguished Professor and Head of Biochemistry and Molecular Biophysics, along with Philip A Cole, MD, PhD, Professor Biological Chemistry & Molecular Pharmacology at Harvard Medical School, received a new three year grant award from The National Science Foundation for their research entitled “Collaborative Research: MFB: Deciphering the Logic of PTM Crosstalk via Novel Chemical Technology: Histones and Beyond”.

All Publications / Holehouse Publications

A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation

Yanniv Dorone, Steven Boeynaems, Eduardo Flores, Benjamin Jin, Shannon Hateley, Flavia Bossi, Elena Lazarus, Janice G. Pennington, Emiel Michiels, Mathias De Decker, Katlijn Vints, Pieter Baatsen, George W. Bassel, Marisa S. Otegui, Alex S. Holehouse, Moises Exposito-Alonso, Shahar Sukenik, Aaron D. Gitler, Seung Y. Rhee (2021). “A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation” Cell. 2021 Aug 5;184(16):4284-4298.e27. doi: 10.1016/j.cell.2021.06.009. Epub 2021 Jul 6. (Abstract)

All Publications / Bowman Publications

SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential

Neha Vithani, Michael D. Ward, Maxwell I. Zimmerman, Borna Novak, Jonathan H. Borowsky, Sukrit Singh, & Gregory R. Bowman (2021). “SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential” Biophys J. 2021 Jul 20;120(14):2880-2889. doi: 10.1016/j.bpj.2021.03.024. Epub 2021 Mar 29. (Abstract)

All Publications / Bowman Publications

SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome

Maxwell I. Zimmerman, Justin R. Porter, Michael D. Ward, Sukrit Singh, Neha Vithani, Artur Meller, Upasana L. Mallimadugula, Catherine E. Kuhn, Jonathan H. Borowsky, Rafal P. Wiewiora, Matthew F. D. Hurley, Aoife M. Harbison, Carl A. Fogarty, Joseph E. Coffland, Elisa Fadda, Vincent A. Voelz, John D. Chodera, & Gregory R. Bowman (2021). “SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome” Nat Chem. 2021 Jul;13(7):651-659. doi: 10.1038/s41557-021-00707-0. Epub 2021 May 24. (Abstract)

All Publications / Greenberg, L. Publications / Greenberg, M. Publications

A Troponin T Variant Linked with Pediatric Dilated Cardiomyopathy Reduces the Coupling of Thin Filament Activation to Myosin and Calcium Binding

Samantha K. Barrick, Lina Greenberg, & Michael J. Greenberg (2021). “A Troponin T Variant Linked with Pediatric Dilated Cardiomyopathy Reduces the Coupling of Thin Filament Activation to Myosin and Calcium Binding” Mol Biol Cell. 2021 Jun 23;mbcE21020082. doi: 10.1091/mbc.E21-02-0082. Online ahead of print. (Abstract)