Department of Biochemistry and Molecular Biophysics

Author: Nicholas Caito

All Publications / Greenberg, M. Publications

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

Adam L. Bailey, Oleksandr Dmytrenko, Lina Greenberg, Andrea L. Bredemeyer, Pan Ma, Jing Liu, Vinay Penna, Lulu Lai, Emma S. Winkler, Sanja Sviben, Erin Brooks, Ajith P. Nair, Kent A. Heck, Aniket S. Rali, Leo Simpson, Mehrdad Saririan, Dan Hobohm, W. Tom Stump, James A. Fitzpatrick, Xuping Xie, Pei-Yong Shi, J. Travis Hinson, Weng-Tein Gi, Constanze Schmidt, Florian Leuschner, Chieh-Yu Lin, Michael S. Diamond, Michael J. Greenberg, & Kory J. Lavine (2021). “SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis” JACC Basic Transl Sci. 2021 Feb 26. doi: 10.1016/j.jacbts.2021.01.002. Online ahead of print. (Abstract)

2021 Spotlights / All Spotlights

Spotlight on Faculty – Li, Weikai

Weikai LiFor over 70 years, the anticoagulant Warfarin has been a first line defense used to treat and prevent heart attacks, strokes, and other cardiovascular diseases. Warfarin inhibits the Human Vitamin K Epoxide Reductase (VKOR) to hinder coagulation. However, despite being the most popular prescribed anticoagulant, Warfarin has a very narrow range of efficacy and overdose often induces severe, sometimes fatal bleeding. In older adults, one-third of hospitalization for adverse drug reaction are due to warfarin use. (more…)

All Publications / Robertson Publications

Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface

Kacey Mersch, Tugba N. Ozturk, Kunwoong Park, Hyun-Ho Lim, & Janice L. Robertson (2021). “Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface” J Mol Biol. 2021 Feb 20;433(8):166886. doi: 10.1016/j.jmb.2021.166886. Online ahead of print. (Abstract)

2021 Research Awards / Niemi / Research Awards

The role of the mitochondrial phosphatase Pptc7 in enabling metabolic flexibility

February 9th, 2021 – Natalie M. Niemi, PhD, Assistant Professor in the department of Biochemistry and Molecular Biophysics, received a one-year pilot and feasibility grant award from the Washington University Diabetes Research Center (DRC), sponsored by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for her research entitled “The role of the mitochondrial phosphatase Pptc7 in enabling metabolic flexibility”.

All Publications / Cooper Publications / Onken Publications

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

Michael D. Onken, Carol M. Makepeace, Kevin M. Kaltenbronn, Joelle Choi, Leonel Hernandez-Aya, Katherine N. Weilbaecher, Kisha D. Piggott, P. Kumar Rao, Carla M. Yuede, Alethia J. Dixon, Patrick Osei-Owusu, John A. Cooper, & Kendall J. Blumer (2021). “Targeting primary and metastatic uveal melanoma with a G protein inhibitor” J Biol Chem. 2021 Feb 9;100403. doi: 10.1016/j.jbc.2021.100403. Online ahead of print. (Abstract)

2021 Research Awards / Research Awards

Multiscale investigation of cardiomyopathy-associated mutations in metavinculin

February 2nd, 2021 – Samantha Kirstin Barrick, PhD, Postdoctoral Scholar in the department of Biochemistry and Molecular Biophysics, and the laboratory of Dr. Michael J. Greenberg, PhD, received a new three year fellowship award from the National Institutes of Health, National Heart, Lung, and Blood Institute for her research entitled “Multiscale investigation of cardiomyopathy-associated mutations in metavinculin”.