Author: Nicholas Caito

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.

Yang B., Vasbinder M., Hird A.W., Su Q., Wang H., Yu Y., Toader D., Lyne P.D., Read J.A., Breed J., Ioannidis S., Deng C., Grondine M., DeGrace N., Whitston D., Brassil P., & Janetka J.W. (2018). “Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.” J Med Chem. doi: 10.1021/acs.jmedchem.7b01490. (Abstract)

2017 David F. Silbert Summer Fellowship

During the summer of 2017, Divya Natarajan, a second-year medical student, was the recipient of the David F. Silbert Summer Fellowship Award.

Supported by this award, Ms. Natarajan performed research in the laboratories of Drs. Rohit Pappu and Ammon Posey in the Department of Biomedical Engineering. Her projected was entitled “Toward Rational Design of Huntington’s Disease Therapeutics Using Profilin as a Model of Huntingtin Aggregation Suppression Via Multivalent Interactions”. (more…)

2017 BMB Holiday Party

On December 16th, 2017, the BMB Department celebrated its annual Holiday Party at the Saint Louis Zoo. Everyone enjoyed the Zoo Wild Lights display, great food and a game of Rudolf the red-nose reindeer.

Click on the following to view more photos or a slideshow of the photos taken at the event.

Jim Janetka’s Paper with David Sibley Highlighted

Congratulations to Drs. Jim Janetka and Amarendar Maddirala, whose publication was selected as the journal cover of the most recent issue of J. Med. Chem, and was the topic of a recent viewpoint entitled “Novel Molecules To Treat Chronic Central Nervous System Toxoplasmosis” by Sandhya Kortagere. (more…)