Author: Nicholas Caito

A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.

Liu G., Nash P.J., Johnson B., Pietzsch C., Ilagan M.X., Bukreyev A., Basler C.F., Bowlin T.L., Moir D.T., Leung D.W., & Amarasinghe G.K. (2017). “A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.” ACS Infect Dis. 2017 Mar 10;3(3):190-198. doi: 10.1021/acsinfecdis.6b00209. Epub 2017 Feb 9. (Abstract)

Joseph Stodola – Olin Biomedical Science Fellow

Congratulations to Joseph Stodola. Joe received the Olin Biomedical Science Fellowship. These Fellowships were created by a generous gift from the Olin Foundation. The Olin Fellowships are presented to Ph.D. and M.D./Ph.D. students conducting research in the biomedical sciences in any Washington University graduate program who have made significant contributions, and demonstrated the potential to become outstanding research scientists. Joe obtained his PhD degree last summer in Peter Burgers’ lab. Next month, he will join Sigma-Aldrich.

Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations.

Soranno A., Holla A., Dingfelder F., Nettels D., Makarov D.E., & Schuler B. (2017). “Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations.” Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1833-E1839. doi: 10.1073/pnas.1616672114. Epub 2017 Feb 21. (Abstract)

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.

Budelier M.M., Cheng W.W., Bergdoll L., Chen Z.W., Abramson J., Krishnan K., Qian M., Covey D.F., Janetka J.W., & Evers A.S. (2017). “Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.” Anal Chem. 2017 Feb 21;89(4):2636-2644. doi: 10.1021/acs.analchem.6b05003. Epub 2017 Feb 9. (Abstract)

Dr. Linda Pike Featured in the Journal of Biological Chemistry

Congratulations to Linda Pike! The Journal of Biological Chemistry included one of her publications among their collection “Highlights of 2016.” The paper is: Ronan et al. Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins. J. Biol. Chem. 291 (11): 5528-5540.
(more…)