Department of Biochemistry and Molecular Biophysics

Author: Conrad Weiland

All Publications / Li Publications

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions

Qing Cao, Zhenyu Hao, Cheng Li, Xuejie Chen, Meng Gao, Nan Jiang, Hongli Liu, Yan Shen, Haiping Yang, Shujuan Zhang, Aiying Yang, Weikai Li, Jian-Ke Tie & Guomin Shen (2023). “Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions” J Thromb Haemost. 2023 Nov;21(11):3124-3137. doi: 10.1016/j.jtha.2023.06.021. Epub 2023 Jun 29. (Abstract)

All Publications / Janetka Publications / Krezel Publications

Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction

Robert Obermann, Bereket Yemane, Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel, Scott A Wildman & James W Janetka (2024). “Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction” ChemMedChem. 2024 Apr 16;19(8):e202300648. doi: 10.1002/cmdc.202300648. Epub 2024 Mar 5. (Abstract)

All Publications / Janetka Publications

Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19

Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney & James W Janetka (2024). “Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19” J Virol.2024 May 14;98(5):e0190323. doi: 10.1128/jvi.01903-23. Epub 2024 Apr 9. (Abstract)

All Publications / Janetka Publications

Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections

Amarendar Reddy Maddirala, Kevin Tamadonfar, Jerome S Pinkner, Denise Sanick, Scott J Hultgren & James W Janetka (2024). “Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections” J Med Chem. 2024 Mar 14;67(5):3668-3678. doi: 10.1021/acs.jmedchem.3c02128. Epub 2024 Feb 3. (Abstract)

All Publications / Janetka Publications

HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis

Alpha Raj Mekapogu, Zhihong Xu, Srinivasa Pothula, Chamini Perera, Tony Pang, S M Zahid Hosen, Vishnu Damalanka, James Janetka, David Goldstein, Romano Pirola, Jeremy Wilson & Minoti Apte (2023). “HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis” Cancer Lett. 2023 Aug 1:568:216286. doi: 10.1016/j.canlet.2023.216286. Epub 2023 Jun 22. (Abstract)

All Publications / Janetka Publications

Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis

Denis Belitškin, Pauliina Munne, Shishir M Pant, Johanna M Anttila, Ilida Suleymanova, Kati Belitškina, Daniel Kirchhofer, James Janetka, Taivo Käsper, Sami Jalil, Jeroen Pouwels, Topi A Tervonen & Juha Klefström (2024). “Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis” Mol Oncol. 2024 Mar;18(3):547-561. doi: 10.1002/1878-0261.13545. Epub 2023 Nov 13. (Abstract)

All Publications / Janetka Publications

Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer

Vivian Truong Jones, Ramona Graves-Deal, Zheng Cao, Galina Bogatcheva, Marisol A Ramirez, Sarah J Harmych, James N Higginbotham, Vineeta Sharma, Vishnu C Damalanka, Claudia C Wahoski, Neeraj Joshi, Maria Johnson Irudayam, Joseph T Roland, Gregory D Ayers, Qi Liu, Robert J Coffey, James W Janetka & Bhuminder Singh (2024). “Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer” Cell Mol Life Sci. 2024 Jan 12;81(1):28. doi: 10.1007/s00018-023-05071-5. (Abstract)

2024 News / All News

Congratulations to Jasmine Cubuk and Keri-Lyn Kozul for receiving the 2024 W.M. Keck Postdoctoral Fellowship award!

Cubuk&Kozul This fellowship provides one year of funding to postdoctoral appointees in the early phase of their postdoctoral training who demonstrate exceptional potential for becoming leading experts in biomedical research.

Dr. Jasmine Cubuk is doing her postdoctoral work in the laboratory of Dr. Andrea Soranno. Dr. Keri-Lyn Kozul is doing her postdoctoral work in the laboratory of Dr. Natalie Niemi.