Category: All Publications

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.

Han Z., Pinkner J.S., Ford B., Chorell E., Crowley J.M., Cusumano C.K., Campbell S., Henderson J.P., Hultgren S.J., and Janetka J.W. (2012) “Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides.” J Med Chem. 2012 Apr 26;55(8):3945-59. doi: 10.1021/jm300165m. Epub 2012 Apr 13. (Abstract)

The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.

Shu Q., Crick S.L., Pinkner J.S., Ford B., Hultgren S.J., & Frieden C. (2012). “The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.” Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6502-7. doi: 10.1073/pnas.1204161109. Epub 2012 Apr 9. (Abstract)

Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.

Tang Y.T., Gao R., Havranek J.J., Groisman E.A., Stock A.M., and Marshall G.R. (2012) “Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.” Chem Biol Drug Des. 2012 Jun;79(6):1007-17. doi: 10.1111/j.1747-0285.2012.01362.x. Epub 2012 Mar 21. (Abstract)