Author: Nicholas Caito

Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging.

Qui H., Zhu Y., Sun Z., Trzeciakowski J.P., Gansner M., Depre C., Resuello R.R., Natividad F.F., Hunter W.C., Genin G.M., Elson E.L., Vatner D.E., Meininger G.A., & Vatner S.F. (2010). “Short communication: vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging.” Circ Res. 2010 Sep 3;107(5):615-9. doi: 10.1161/CIRCRESAHA.110.221846. Epub 2010 Jul 15. (Abstract)

Discovery of a novel class of triazolones as checkpoint kinase inhibitors–hit to lead exploration.

Oza V., Ashwell S., Brassil P., Breed J., Deng C., Ezhuthachan J., Haye H., Horn C., Janetka J., Lyne P., Newcombe N., Otterbien L., Pass M., Read J., Roswell S., Su M., Toader D., Yu D., Yu Y., Valentine A., Webborn P., White A., Zabludoff S., and Zheng X.
Discovery of a novel class of triazolones as checkpoint kinase inhibitors–hit to lead exploration.
Bioorg Med Chem Lett. 20(17):5133-8. doi: 10.1016/j.bmcl.2010.07.015. (2010) (Abstract)

Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.

Chen Z., Datta S., Dubois J.L., Klinman J.P., & Mathews F.S. (2010). “Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.” Biochemistry. 2010 Aug 31;49(34):7393-402. doi: 10.1021/bi100643y. (Abstract)

Electron paramagnetic resonance studies of functionally active, nitroxide spin-labeled peptide analogues of the C-terminus of a G-protein alpha subunit.

Van Eps N., Anderson L.L., Kisselev O.G., Baranski T.J., Hubbell W.L., and Marshall G.R. (2010) “Electron paramagnetic resonance studies of functionally active, nitroxide spin-labeled peptide analogues of the C-terminus of a G-protein alpha subunit.” Biochemistry. 2010 Aug 17;49(32):6877-86. doi: 10.1021/bi100846c. (Abstract)

Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.

Yang K.S., Macdonald-Obermann J., Piwnica-Worms D., & Pike L.J. (2010). “Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.” J Biol Chem. 2010 Jul 30;285(31):24014-22. doi: 10.1074/jbc.M110.103317. Epub 2010 May 27. (Abstract)