Department of Biochemistry and Molecular Biophysics

Author: Nicholas Caito

All Publications / Frieden Publications

Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase

Mathivanan Chinnaraj, David A. Barrios, Carl Frieden, Tomasz Heyduk, Robert Flaumenhaft, & Nicola Pozzi. (2020). “Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase” Chembiochem. 2020 Aug 28. doi: 10.1002/cbic.202000537. Online ahead of print. (Abstract)

All Research / Niemi Lab

Spotlight on Research – Niemi Lab

The Niemi Lab investigates how mitochondria are built, regulated, and maintained across physiological contexts. We blend biochemistry, systems biology, and physiology to understand mechanisms of mitochondrial regulation and how they influence metabolism and organellar function. Using insights gained from our molecular studies, we aim to understand how mitochondrial dysfunction contributes to mammalian pathophysiology, with the long-term goal of translating our discoveries into new therapeutic options to restore mitochondrial function in human disease.


Mechanisms of mitochondrial biogenesis, regulation, and turnover.

All Publications / Li Publications

Open conformation of tetraspanins shapes interaction partner networks on cell membranes

Yihu Yang, Xiaoran Roger Liu, Zev J. Greenberg, Fengbo Zhou, Peng He, Lingling Fan, Shixuan Liu, Guomin Shen, Takeshi Egawa, Michael L. Gross, Laura G. Schuettpelz, & Weikai Li (2020). “Open conformation of tetraspanins shapes interaction partner networks on cell membranes” EMBO J (2020) e105246. 2020-08-16. doi: 10.15252/embj.2020105246. (Abstract)

All Publications / Li Publications

Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay

Wenwen Gao, Yaqi Xu, Hongli Liu, Meng Gao, Qing Cao, Yiyi Wang, Longteng Cui, Rong Huang, Yan Shen, Sanqiang Li, Haiping Yang, Yixiang Chen, Chaokun Li, Haichuan Yu, Weikai Li, & Guomin Shen. (2020). “Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay” Blood Adv. 2020 Aug 11;4(15):3659-3667. doi: 10.1182/bloodadvances.2020002520. (Abstract)

2020 Research Awards / Research Awards / Zhang

Structural and functional studies of axonemal microtubule inner proteins (MIPs)

July 10th, 2020 – Rui Zhang, PhD, assistant professor of biochemistry and molecular biophysics received a new five year grant award from the National Institute of General Medical Sciences for his research entitled “Structural and functional studies of axonemal microtubule inner proteins (MIPs)”.

All Publications / Bowman Publications

Citizen Scientists Create an Exascale Computer to Combat COVID-19

Maxwell I. Zimmerman, Justin R. Porter, Michael D. Ward, Sukrit Singh, Neha Vithani, Artur Meller, Upasana L. Mallimadugula, Catherine E. Kuhn, Jonathan H. Borowsky, Rafal P. Wiewiora, Matthew F. D. Hurley, Aoife M. Harbison, Carl A. Fogarty, Joseph E. Coffland, Elisa Fadda, Vincent A. Voelz, John D. Chodera, & Gregory R. Bowman (2020). “Citizen Scientists Create an Exascale Computer to Combat COVID-19” bioRxiv. 2020 Jun 28;2020.06.27.175430. doi: 10.1101/2020.06.27.175430. Preprint (Abstract)

2020 News / All News

Dr. Greg Bowman Featured in The Source

Folding@home’s fight against COVID-19 enlists big tech, gamers, pro soccer

When the crowdsourced supercomputing project Folding@home first announced a shift to coronavirus research and asked for new volunteers to run its software and expand its computing capacity, organizations and citizen scientists from all walks of life heeded the call. Now, about four months later, the number of volunteers has increased a hundredfold. To continue reading, click here.