Antonija Kuzmanic, Gregory R. Bowman, Jordi Juarez-Jimenez, Julien Michel, & Francesco L. Gervasio (2020). “Investigating Cryptic Binding Sites by Molecular Dynamics Simulations” Acc Chem Res. 2020 Mar 17;53(3):654-661. doi: 10.1021/acs.accounts.9b00613. Epub 2020 Mar 5. (Abstract)
Joanna Kim & John A. Cooper (2020). “Septin Roles and Mechanisms in Organization of Endothelial Cell Junctions” bioRxiv. doi: https://doi.org/10.1101/2020.03.04.977199 (Abstract)
Jordan E. Ezekian, Sarah R. Clippinger, Jaquelin M. Garcia, Qixin Yang, Susan Denfield, Aamir Jeewa, William J. Dreyer, Wenxin Zou, Yuxin Fan, Hugh D. Allen, Jeffrey J. Kim, Michael J. Greenberg, & Andrew P. Landstrom (2020). “Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction” J Am Heart Assoc. 2020 Mar 3;9(5):e015111. doi: 10.1161/JAHA.119.015111. Epub 2020 Feb 26. (Abstract)
Rawlings A.E., Liravi P., Corbett S., Holehouse A.S., & Staniland S.S. (2020). “Investigating the ferric ion binding site of magnetite biomineralisation protein Mms6.” PLoS One. 2020 Feb 25;15(2):e0228708. doi: 10.1371/journal.pone.0228708. eCollection 2020. (Abstract)
A recent publication in PNAS (Clippinger et al.) from the Greenberg lab was highlighted in Circulation. The Greenberg lab demonstrated how a mutation that causes genetic heart failure affects not only how the proteins in the heart generate force, but also how heart cells respond to changes in their mechanical environment. This work has important implications for the development of new precision medicine therapies for heart failure.
The highlight can be found here and the PNAS article can be found here.
Matthew A. Cruz, Thomas E. Frederick, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, & Gregory R. Bowman (2020). “Discovery of a cryptic allosteric site in Ebola’s ‘undruggable’ VP35 protein using simulations and experiments” bioRxiv. doi: https://doi.org/10.1101/2020.02.09.940510 (Abstract)
Martin E.W., Holehouse A.S., Peran I., Farag M., Incicco J.J., Bremer A., Grace C.R., Soranno A., Pappu R.V., & Mittag T. (2020). “Valence and patterning of aromatic residues determine the phase behavior of prion-like domains.” Science. 2020 Feb 7;367(6478):694-699. doi: 10.1126/science.aaw8653. (Abstract)
Greig J.A., Nguyen T.A., Lee M., Holehouse A.S., Posey A.E., Pappu R.V., & Jedd G. (2020). “Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation.” Mol Cell. 2020 Feb 6. pii: S1097-2765(20)30046-0. doi: 10.1016/j.molcel.2020.01.025. [Epub ahead of print] (Abstract)
On January 30, 2020, the John E. Majors award was presented to Drs. Sarem Hailemariam, Brian Lananna and Elizabeth Mathyer. Each recipient presented their research, teaching and mentorship accomplishments.
For more information on each recipient, please click here
Choi J.M., Holehouse A.S., & Pappu R.V. (2020). “Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions.” Annu Rev Biophys. 2020 Jan 31. doi: 10.1146/annurev-biophys-121219-081629. [Epub ahead of print] (Abstract)