Author: Nicholas Caito

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

James Brett Case, Paul W Rothlauf, Rita E Chen, Zhuoming Liu, Haiyan Zhao, Arthur S Kim, Louis-Marie Bloyet, Qiru Zeng, Stephen Tahan, Lindsay Droit, Ma Xenia G Ilagan, Michael A Tartell, Gaya Amarasinghe, Jeffrey P Henderson, Shane Miersch, Mart Ustav, Sachdev Sidhu, Herbert W Virgin, David Wang, Siyuan Ding, Davide Corti, Elitza S Theel, Daved H Fremont, Michael S Diamond, & Sean P J Whelan (2020). “Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2” bioRxiv. 2020 May 18;2020.05.18.102038. doi: 10.1101/2020.05.18.102038. Preprint (Abstract)

Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts

John T. Petroff 2nd, Ailing Tong, Lawrence J. Chen, Gregory T. Dekoster, Farha Khan, Jeff Abramson, Carl Frieden, & Wayland W. L. Cheng (2020). “Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts” Anal Chem. 2020 May 5;92(9):6622-6630. doi: 10.1021/acs.analchem.0c00454. Epub 2020 Apr 14. (Abstract)

Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance

April 24th, 2020 – Timothy M. Lohman, PhD, Marvin A. Brennecke Professor of Biophysics and professor of biochemistry and molecular biophysics received a new five year MIRA grant award from National Institute of General Medical Sciences for his research entitled “Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance”.

Remembrance of Dr. Drysdale

George R. DrysdaleDr. George Drysdale, emeritus faculty member of our department, died March 17, 2020. We are saddened by the loss of our friend and colleague. Dr. Drysdale was a member of our department from 1954, when he arrived as a postdoctoral fellow to work with Mildred Cohn. He joined the faculty of the department in 1957 and continued as a member of our department faculty for the rest of his life.

Several of his colleagues, including his close friend Carl Frieden, have provided remembrances. To read them, click here. If you wish to add your remembrances, feel free to send us a message at torresm@wustl.edu or jacooper@wustl.edu.

Spotlight on Faculty – Soranno, Andrea


Andrea SorannoIlluminating the Invisible: The Soranno Lab’s Study of APOE4 Conformations

Alzheimer’s disease is a ruthless, progressive neurodegenerative disease that induces memory loss and neuronal death in patients. With more than 3 million new cases each year in the United States alone, this disease likely plagues someone you know. Despite extensive research efforts, there is no cure for Alzheimer’s disease. However, using a new high-tech approach, the Soranno lab may have a new way to elucidate part of the disease from the inside out. (more…)

Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance.

Brown C.A., Hu L., Sun Z., Patel M.P., Singh S., Porter J.R., Sankaran B., Prasad B.V.V., Bowman G.R., & Palzkill T. (2020). “Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance.” J Biol Chem. 2020 Apr 16. pii: jbc.RA119.012489. doi: 10.1074/jbc.RA119.012489. [Epub ahead of print] (Abstract)

Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein

Patrick McConnell, Marlene Mekel, Alex G. Kozlov, Olivia L. Mooren, Timothy M. Lohman, & John A. Cooper (2020). “Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein” Biochemistry. 2020 Mar 24;59(11):1202-1215. doi: 10.1021/acs.biochem.0c00092. Epub 2020 Mar 10. (Abstract)

2020 BMB Department Retreat

On March 5th, 2020, the Department held a half day retreat at the Eric P. Newman Center located on the WU Medical Campus. All of the labs in the department introduced their lab members and questions their lab is working on in their lab.

You can click here to view photos from the event.

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.

Hohl M., Mojumdar A., Hailemariam S., Kuryavyi V., Ghisays F., Sorenson K., Chang M., Taylor B.S., Patel D.J., Burgers P.M., Cobb J.A., & Petrini J.H.J. (2020). “Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.” PLoS Genet. 2020 Mar 18;16(3):e1008422. doi: 10.1371/journal.pgen.1008422. [Epub ahead of print] (Abstract)