Young Ah Goo – Director, Mass Spectrometry Technology Access Center (MTAC)
Office: Mass Spectrometry Technology Access Center
Phone: 314-273-3487
E-mail: ygoo@wustl.edu
Mass spectrometry-based multi-omics; Proteomics, Metabolomics, Lipidomics, Mass Spectrometry Imaging
Maureen McCaffrey – Administrative Coordinator
Office: 2901 SB – Admin Staff
E-mail: mmaureen@wustl.edu
Hema Adhikari – Assistant Professor
Office: 2812 NB
Phone: 314-273-6748
E-mail: hema.adhikari@wustl.edu
Molecular architecture of cancer cell signaling networks in tumorigenesis & drug resistance.
Ankita did her MS in Medical Biochemistry at Sardar Patel Medical College in India. She joined DRSCB program through the Division of Biology and Biomedical Sciences at Washington University in Saint Louis in 2018 and is pursuing PhD in the lab of Dr. Eric Galburt in the Department of Biochemistry and Molecular Biophysics.
Ankita’s graduate research is focused on characterizing the activation mechanisms of a helicase and DNA repair protein called UvrD1 from Mycobacterium tuberculosis. She is using quantitative assays like analytical ultracentrifugation to determine the oligomeric status and stopped flow kinetics to measure DNA unwinding by UvrD1 in presence and absence of accessory factors.
Yixuan (Axe) Xie, Ph.D., is a postdoctoral research associate in the laboratory of Dr. Benjamin Garcia, where he focused on developing MS-based methods to characterize protein and RNA modifications for understanding their biological roles. He is also interested in investigating the interactions network involved in glycoproteins. He obtained his Ph.D. at the University of California, Davis, under the mentorship of Dr. Carlito Lebrilla. During his Ph.D., he established bioorthogonal tools to investigate the glycan-mediated interactions on the cell surface, as well as glycoproteomic and glycomic methods to monitor the cell glycosylation state during significant biological events.
Garland Marshall – Professor Emeritus
E-mail: garland@wustl.edu
Major focus is molecular recognition – the basis of intermolecular interactions and specificity seen in drug and hormone receptors, antigen-antibody and substrate-enzyme systems.
Oct 1st 2022 – Alex Holehouse, assistant professor of biochemistry and molecular has received $380,000 in funding from the Human Frontiers Science Program (HFSP) to lead a three-year project titled “Molecular determinants of evolutionary conservation in disordered protein regions”. This project will integrate computational and experimental approaches to uncover who intrinsically disordered protein regions evolve. The proposal involves co-investigators Dr. Hyun Kate Lee (University of Toronto, CA) and Dr. Dolf Weijers (Wageningen University, NL).
Oct 1st 2022 – Alex Holehouse, assistant professor of biochemistry and molecular has received more than $450,000 in funding from the National Science Foundation (NSF) to lead a five-year project titled “Molecular engineering to understand desiccation protection and water responsiveness.” The project is part of a larger grant called “Life without water: protecting macromolecules, cells, and organisms during desiccation and rehydration across kingdoms of life.” This grant establishes the Water and Life Interface Institute led by Carnegie Science (https://www.walii.science/). The new initiative includes collaborators from at least nine research institutions nationwide.
Garrett M. Ginell & Alex S. Holehouse (2022). “An Introduction to the Stickers-and-Spacers Framework as Applied to Biomolecular Condensates” Methods Mol Biol. 2023;2563:95-116. doi: 10.1007/978-1-0716-2663-4_4. (Abstract)
