Author: Nicholas Caito
Human heart-on-a-chip to study the immune system in cardiac disease pathogenesis and repair
July 1st, 2022 – Michael Greenberg, PhD, Associate Professor of Biochemistry and Molecular Biophysics along with Kory J. Lavine, MD PhD, Associate Professor of Medicine and Nathaniel D. Huebsch, PhD, Assistant Professor of Biomedical Engineering have received a new three-year grant award from American Heart Association for their research entitled “Human heart-on-a-chip to study the immune system in cardiac disease pathogenesis and repair”.
Aspartyl Protease Inhibitors as Anti-Filarial Drugs
Liana Beld, Hyeim Jung, Christina A. Bulman, Bruce A. Rosa, Peter U. Fischer, James W. Janetka, Sara Lustigman, Judy A. Sakanari, and Makedonka Mitreva (2022). “Aspartyl Protease Inhibitors as Anti-Filarial Drugs” Pathogens. 2022 Jun 18;11(6):707. doi: 10.3390/pathogens11060707. (Abstract)
Anna Damato selected as 2022 Ceil M. DeGutis Prize Fellow
Anna Damato is a fifth-year PhD candidate in Neuroscience in the Department of Biology. Anna was nominated for this award by her thesis mentor, Dr. Erik Herzog, in whose lab she is connecting the bench to the bedside by investigating mechanisms of glioblastoma brain tumor circadian rhythms and how they impact the efficacy of chemotherapy. Anna uses real-time bioluminescence reporters of circadian gene expression to analyze the effects of timed treatment, with the goal of maximizing anti-tumor effects and minimizing side effects of chemotherapy in treating an otherwise dismal disease. In addition to cellular and molecular studies, Anna collaborates with physicians at the Siteman Cancer Center to assess benefits of timed chemotherapy in patients with brain cancer. (more…)
A multipronged investigation of SARS-CoV-2 genome packaging
April 22nd, 2022 – Andrea Soranno, PhD, Assistant Professor of Biochemistry and Molecular Biophysics along with Kathleen Hall, PhD, Professor of Biochemistry and Molecular Biophysics and Alex Holehouse, PhD, Assistant Professor of Biochemistry and Molecular Biophysics have received a new five-year grant from National Institute of Allergy and Infectious Diseases for their research entitled “A multipronged investigation of SARS-CoV-2 genome packaging”
How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein
Alexander G. Kozlov, Xian Cheng, Hongshan Zhang, Min Kyung Shinn, Elizabeth Weiland, Binh Nguyen, Irina A. Shkel, Emily Zytkiewicz, Ilya J. Finkelstein, M. Thomas Record Jr., & Timothy M. Lohman (2022). “How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein” J Mol Biol. 2022 Mar 26;434(9):167562. doi: 10.1016/j.jmb.2022.167562. Online ahead of print.