December 19th, 2016 – Timothy M. Lohman, PhD, professor of biochemistry and molecular biophysics received a four year grant award from the National Institute of General Medical Sciences for his research entitled “Helicase Catalyzed DNA Unwinding”.
A story about Jim Janetka’s research on antibiotic-sparing therapeutics, prompted by his new paper in J Med Chem, has just published in The Record. His research group has developed small molecules that prevent bacteria from sticking to the bladder wall, halting development of urinary tract infections in mice. (more…)
Galburt E.A. & Rammohan J. (2016). “A Kinetic Signature for Parallel Pathways: Conformational Selection and Induced Fit. Links and Disconnects between Observed Relaxation Rates and Fractional Equilibrium Flux under Pseudo-First-Order Conditions.” Biochemistry. 2016 Dec 20;55(50):7014-7022. Epub 2016 Dec 8. (Abstract)
Yang Y., Ke N., Liu S., & Li W. (2016). “Methods for Structural and Functional Analyses of Intramembrane Prenyltransferases in the UbiA Superfamily.” Methods Enzymol. 2017;584:309-347. doi: 10.1016/bs.mie.2016.10.032. Epub 2016 Dec 7. (Abstract)
Brosey C.A., Ho C., Long W.Z., Singh S., Burnett K., Hura G.L., Nix J.C., Bowman G.R., Ellenberger T., & Tainer J.A. (2016). “Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor” Structure. 2016 Dec 6;24(12):2067-2079. doi: 10.1016/j.str.2016.09.012. Epub 2016 Nov 3. (Abstract)
Shen G., Cui W., Zhang H., Zhou F., Huang W., Liu Q., Yang Y., Li S., Bowman G.R., Sadler J.E., Gross M.L., & Li W. (2017). “Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer.” Nat Struct Mol Biol. 2017 Jan;24(1):69-76. doi: 10.1038/nsmb.3333. Epub 2016 Dec 5. (Abstract)
2016-12-06 – Jonathan P. Staley, Ph.D. – University of Chicago – “The Function and Mechanism of DEAH box ATPases at the Catalytic Stage of Splicing” (more…)
Kochenova O.V., Bezalel-Buch R., Tran P., Makarova A.V., Chabes A., Burgers P.M., & Shcherbakova P.V. (2016). “Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.” Nucleic Acids Res. 2017 Feb 17;45(3):1200-1218. doi: 10.1093/nar/gkw1149. (Abstract)
2016-11-29 – Maria Kontoyianni, Ph.D. – Southern Illinois University, Edwardsville – “A Computational Strategy to Probe Cytochrome P450 3A4-Drug Complexes” (more…)
Kraft T.E., Heitmeier M.R., Putanko M., Edwards R.L., Ilagan M.X., Payne M.A., Autry J.M., Thomas D.D., Odom A.R., and Hruz P.W. (2016) “A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.” Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. Print 2016 Dec. (Abstract)