November 18th, 2016 – Xianqiang Sun
2016-11-18 – Xianqiang Sun (Bowman Lab) – Molecular mechanism of GDP release by G proteins
Author: Nicholas Caito
Protein Modeling from Cryo-EM DensityMaps Using Geometric Skeletons
2016-12-13 – Tao Ju, Ph.D. – Protein Modeling from Cryo-EM DensityMaps Using Geometric Skeletons (more…)
A Prescription for Change: The Looming Crisis in Drug Development
Michael Kinch (2016) “A Prescription for Change: The Looming Crisis in Drug Development” (ISBN-13: 978-1469630625, ISBN-10: 1469630621)
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Needham S.R., Roberts S.K., Arkhipov A., Mysore V.P., Tynan C.J., Zanetti-Domingues L.C., Kim E.T., Losasso V., Korovesis D., Hirsch M., Rolfe D.J., Clarke D.T., Winn M.D., Lajevardipour A., Clayton A.H., Pike L.J., Perani M., Parker P.J., Shan Y., Shaw D.E., & Martin-Fernandez M.L. (2016). “EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.” Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307. (Abstract)
Therapeutics Targeting Filoviral Interferon-Antagonist and Replication Functions
November 1st, 2016 – Dr. Gregory Bowman, Assistant Professor of Biochemistry and Molecular Biophysics received a two year subcontract from the National Institute of Allergy and Infectious Diseases. This project is a subcontract with Drs. Gaya Amarsinghe (Wash U) and Christopher Basler (Georgia State University) for his project entitled “Therapeutics Targeting Filoviral Interferon-Antagonist and Replication Functions”.
Congratulations to Drake Jensen for being named the 2016 Gary K. Ackers Fellow
Mr. Jensen received his B.A. in Chemistry and B.S. in Biology from Southern Illinois University Edwardsville in 2013. During this time, he began pursuing research in equilibrium and kinetic studies of Calmodulin target recognition. (more…)
2016 David F. Silbert Summer Fellowship
This summer, Margery Gang, a second-year medical student, was the recipient of the David F. Silbert Summer Fellowship award.
Supported by this award, Ms. Gang performed research in the laboratories of Drs. Matthew Christopher and Timothy Ley in the Division of Oncology of the Department of Medicine. Her project was entitled “WT1 loss-of-function mutations in Acute Myeloid Leukemia”. (more…)
Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.
Mydock-McGrane L., Cusumano Z., Han Z., Binkley J., Kostakioti M., Hannan T., Pinkner J.S., Klein R.D., Kalas V., Crowley J., Rath N.P., Hultgren S.J., & Janetka J.W. (2016). “Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.” J Med Chem. 2016 Oct 27;59(20):9390-9408. Epub 2016 Oct 14. (Abstract)
Energy-landscape engineering: exploiting proteins uncharted conformations
October 14th, 2016 – Dr. Gregory Bowman, Assistant Professor of Biochemistry and Molecular Biophysics, has been chosen to receive a 2016 Packard Fellowship for Science and Engineering in support of his research entitled “Energy-landscape engineering: exploiting proteins uncharted conformations”. (more…)