March 18th, 2016
2016-03-18 – Shixuan Liu (Li Lab) – Structural Study on Membrane Protein Vitamin K Epoxide Reductase (VKOR)
Author: Nicholas Caito
α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer.
Han Z., Harris P.K.W., Karmakar P., Kim T., Owusu B.Y., Wildman S.A., Klampfer, L., & Janetka J.W. (2016). “α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer.” ChemMedChem. 2016 Mar 17;11(6):585-99. doi: 10.1002/cmdc.201500600. Epub 2016 Feb 17. (Abstract)
Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.
Simpson C., Jones N.G., Hull-Ryde E.A., Kireev D., Stashko M., Tang K., Janetka J., Wildman S.A., Zuercher W.J., Schapira M., Hui R., Janzen W., & Sibley L.D. (2016). “Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.” ACS Infect Dis. 2016 Mar 11;2(3):194-206. Epub 2015 Dec 28. (Abstract)
March 11th, 2016
2016-03-11 – Rotation Talks:
George Katumba – CueO: A Multicopper Oxidase with a Role in Cu Homeostasis in
E. coli
Justin Miller – Dissecting the Role of RNA Polymerase Binding Protein A in Mycobacteria
Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.
Ronan T., Macdonald-Obermann J.L., Huelsmann L., Bessman N.J., Naegle K.M., & Pike L.J. (2016). “Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.” J Biol Chem. 2016 Mar 11;291(11):5528-40. doi: 10.1074/jbc.M115.710087. Epub 2016 Jan 19. (Abstract)
Vascularizing Engineered (cardiac and tumor) Tissue in vitro
2016-03-08 – Steven George – Vascularizing Engineered (cardiac and tumor) Tissue in vitro
Accurately modeling nanosecond protein dynamics requires at least microseconds of simulation.
Bowman G.R.
Accurately modeling nanosecond protein dynamics requires at least microseconds of simulation.
J Comput Chem. 37(6):558-66. (2016) (Abstract)
March 4th, 2016
2016-03-04 – Qin Shu (Frieden Lab) – Solution NMR Structure CsgE: Structural Insights into a Chaperone and Regulator Protein in Curli Secretion and Biogenesis
Mechanisms of backtrack recovery by RNA polymerases I and II.
Lisica A., Engel C., Jahnel M., Roldán É., Galburt E.A., Cramer P., & Grill S.W. (2016). “Mechanisms of backtrack recovery by RNA polymerases I and II.” Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2946-51. doi: 10.1073/pnas.1517011113. Epub 2016 Feb 29. (Abstract)
develop models of familial cardiomyopathies using stem cells
February 27th, 2016 – Michael Greenberg, PhD, assistant professor of biochemistry and molecular biophysics received received an award from the CDI hPSC Pilot Grant Program to develop models of familial cardiomyopathies using stem cells.